Graduated in Medicine in 1953. From 1957 to 1985, worked at the Medical School of Ribeirão Preto-USP. From 1985 to 2010: chaired the Hypertension Unit, Heart Institute of the Medical School of the University of São Paulo (InCor-FMUSP). His main research field is experimental and clinical hypertension, especially the neurogenic mechanism. From 1993 to 2007: President of the Brazilian Academy of Sciences. From 1998 to 2002: Chairman of the Committee on Science and Technology in Developing Countries (COSTED) of the International Council of Science. From 2000 to 2003: co-chairman of the InterAcademy Pannel-IAP, representing Brazil at the Executive Committee of the InterAcademy Council-IAC (2000-2010), and the Inter-Academy Medical Panel (2010-).He is currently the director for International Relations of the Medical School of the University of São Paulo, member of the National Council of Science and Technology, and the Vice-President of São Paulo Research Foundation (FAPESP).