Padrón is emeritus investigator, Center of Structural Biology, Venezuelan Institute for Scientific Research (IVIC), Caracas. After his postdoctoral work at the MRC Laboratory of Molecular Biology (Cambridge, UK), he founded the Dept. of Structural Biology of IVIC in 1997, where he was an international research scholar of the Howard Hughes Medical Institute until 2011. He has devoted his career to the study of the structure and function of the myosin thick filaments of skeletal, cardiac and smooth muscle and the myosin interacting-head motif (IHM) structure and function, with their implications on the muscle relaxed state, super-relaxation, thick filament activation and human muscle diseases like hypertrophic and dilated cardiomyopathy. His honors include: Polar Prize (1991); CONICIT Biology Prizes (1989, 1990, 1996); FONACIT Biology Prize (2005); and the National Prize in Science and Technology of Venezuela (2008). He is a member of the Latin-American Academy of Sciences (ACAL).