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Instituto de Química – Universidade de São Paulo – Av. Lineu Prestes, 748- 05508-900 São Paulo, SP – Brazil
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Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo
I am Full Professor of Biochemistry at the Departamento de Bioquímica, Instituto de Químca, Universidade de São Paulo and currently, Director of the Research, Innovation and Dissemination Center for Redox Processes in Biomedicine (Redoxoma) (http://redoxoma.iq.usp.br/). My research interests have always been focused in the understanding of the multiple roles of free radicals and oxidants in physiology and pathophysiology. Among my contributions to the redox biology filed, it can be mentioned the establishment that carbon-centered radicals can alkylate biomolecules and that the carbonate radical and nitrogen dioxide are relevant bioradicals. While studying production of the carbonate radical by human superoxide dismutase 1 (hSOD1) she showed that attack of the radical on the enzyme produced novel cross-links, ditryptophan cross-links. I am studying further aspects of these cross-links, including their potential role in protein aggregation diseases, I am also interested on the mechanism by which the bicarbonate buffer accelerates biological oxidations. .
Sustainable Development Goals:
3 - Good health and well-being
4 - Quality education
5 - Gender equality
9 - Industry, innovation and infrastructure
16 - Peace, justice and strong institutions
17 - Partnerships for the goals
Chemistry and biochemistry of free radicals and oxidants; redox processes in biology; applications of EPR to biomedical problems.
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