Figueiredo Claudia

The research area of Figueiredo is neuroscience focused in understand the pathological neuroimmune modulation that occurs in neurodegenerative diseases, aiming the development of preventive or therapeutics strategies to theses conditions. In one of her first projects as an independent researcher, she used mouse model of sepsis to study the late cognitive impairment associated to this condition. We found that a disrupted hippocampal insulin signalling is linked to memory impairment in sepsis-surviving mice, similarly to what has been described in AD models. Her research group also published important findings related to the alpha-synuclein oligomers, an important toxin associated to Parkinson’s disease. During her career, she has developed a strong and broad background in the study of the fundamental mechanisms that modulate neurodegenerative diseases. She is affiliated member of the Brazilian Academic Science and published more than 50 peer-reviewed papers on topics related to pharmacology and neuroscience. Actually she is proposing a challenging project to elucidate neuroimmune mechanisms involved in Zika Virus infection in the adult central nervous system.