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Public contact information

Phone: 
+58 212 504 1434
Address: 
Centro de Biología Estructural "Humberto Fernández-Morán", IVIC, APDO 20632, Caracas 1020A, Venezuela.
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Fellow
Padrón
Raúl Alejandro
Current position: 
Emeritus Investigator, Center of Structural Biology, Venezuelan Institute for Scientific Research (I.V.I.C.), Caracas, Venezuela
Current nationality: 
Venezuela
Current residence: 
Venezuela
Affiliation/Institution: 
Emeritus Investigator, Center of Structural Biology, Venezuelan Institute for Scientific Research (I.V.I.C.), Caracas, Venezuela
Biodata: 
Padrón work started at Cambridge´s MRC Laboratory of Molecular Biology. He founded I.V.I.C.´s Center of Structural Biology, where he was an International Research Scholar of Howard Hughes Medical Institute. His lab and collaborators found: (1) by cryo-EM that in thick filaments of tarantula muscle the two heads form the myosin interacting-heads motif (IHM), where both ATPases were inhibited explaining relaxation (Nature 436: 1195, 2005). (2) that IHM is conserved since before the origin of animals revealing IHM importance as a relaxation ATPase inhibition and ATP energy-saving mechanism. (3) that a cooperative phosphorylation activation mechanism explains potentiation and post-tetanic potentiation on tarantula contracting muscles. (4) that mutations of hypertrophic cardiomyopathy concentrate on human cardiac IHM intramolecular interactions accounting for altered contractility, reduced diastolic relaxation, and increased energy consumption. Honors: Polar Prize, CONICIT and FONACIT Biology Prizes and National Prize in Science and Technology of Venezuela. Elected member of Latin-American Academy of Sciences (2004) and elected foreign associate of U.S. National Academy of Sciences.
Sustainable Development Goals: 
3 - Good health and well-being
Keywords: 
Structural biology, Muscle, Thick filaments, Myosin 2, Myosin interacting-heads motif (IHM), Thick filament activation, Super-relaxation (SRX), Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM)
Past nationality: 
Venezuela
Elected
2004
Place of Birth: 
Caracas
Country of birth: 
Venezuela

Date of birth

7
May
1950
Section:
02-Structural, Cell and Molecular Biology
Last updated on 05/05/2018