Mpiana has been a professor in the Department of Chemistry and Industry, Faculty of Science and Technology, University of Kinshasa, Democratic Republic of the Congo (DRC), since 2003. In 2022, he started serving as president of the National Scientific Council of DRC, coordinating the activities of the country's research institutions. He is a member of the Congolese Academy of Sciences, where he serves as secretary of the natural sciences section, and a Fellow of the African Academy of Sciences. He is also president of the permanent scientific commission of the Association of Chemists of the DRC, and was a senior associate at the Abdus Salam International Centre for Theoretical Physics (Trieste, Italy), from 2009 to 2015. The editor-in-chief of the Congolese Journal of Science and Technology, he serves on the editorial boards of many scientific journals. He has supervised or co-supervised 17 doctoral theses and securing funding for several research projects. He has received many national awards, including the DRC Diploma and Medal of Scientific Merit, awarded by the Ministry of Higher Education in 2010. He is the author or co-author of 6 books and more than 400 research articles.