Aziz is a professor at the Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University—which he chaired from 2016–2021, and the head of MARC Bioscience Research Laboratories in Giza, Egypt. From 2021–2024, he has directed the Microbiology and Immunology Research Programme at the Children’s Cancer Hospital of Egypt. In 2005, he received his PhD in microbiology and immunology from the University of Tennessee, Health Science Center in Memphis, and carried out postdoctoral research at the University of Chicago, San Diego State University, and UCSD (2008–2013). He collaborates with the Argonne National Laboratory. His research spans microbiology and immunology, genomics of microbial pathogens and phages, and microbiomics. He is a pioneer of pharmacomicrobiomics, a discipline that studies drug-microbiome interactions. He has published more than 120 peer-reviewed articles, a book, nine book sections, and is maintaining two bioinformatics databases. His work has been nationally and internationally acknowledged through awards from TWAS, COMSTECH, and Shoman Awards. He is ranked among the 1% most productive authors in the SCOPUS database (based on c-score).